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National Repository of Grey Literature 1 records found  Search took 0.00 seconds. 
Gastroparesis - pathophysiology, etiopathogenesis and possibilities of endoscopic treatment
 Husťak, Rastislav ; Martínek, Jan (advisor) ; Bureš, Jan (referee) ; Urban, Ondřej (referee)
Background: Gastroparesis (GP) is a disorder characterized by delayed gastric emptying in the absence of a symptomatic mechanical obstruction of the stomach with cardinal symptoms. Two principal pathophysiological mechanisms are believed to be responsible for development of GP: global gastric hypomotility and pylorospasm. As pylorospasm may play an important role in GP, the efficacy of treatment modalities targeting the pylorus, such as gastric peroral endoscopic pyloromyotomy (G-POEM), is currently being intensively studied, as these methods have the potential to help especially patients with severe symptoms for whom other treatment measures are ineffective. The aims of our studies were: (1) to evaluate clinical efficacy of G-POEM in the treatment of patients with severe GP; (2) to evaluate the changes in objective periprocedural parameters measured by gastric emptying study (GES) and functional planimetry; (3) to evaluate safety of G-POEM and (4) to compare the efficacy of two closure methods used to close the mucosal incision in G-POEM: clips and endoscopic suturing (ES). Patients and methods: Patients older > 18y, with gastroparesis cardinal symptoms index (GCSI) > 2.3 and abnormal GES were eligible for inclusion. All projects had been performed between 2015 and 2021. Project (1): Clinical efficacy of...
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